表觀遺傳學(xué)是指基于非基因序列改變所致基因表達水平變化。表觀遺傳的現(xiàn)象目前已知的包括DNA甲基化、基因組印記、母體效應(yīng)、基因沉默、核仁顯性、休眠轉(zhuǎn)座子激活和RNA編輯等。
其中組蛋白（Histone）的修飾作用是表觀遺傳學(xué)研究的一個重要領(lǐng)域。Histone H3與H2A、H2B和H4一起參與真核細胞中染色質(zhì)的結(jié)構(gòu)。組蛋白H3通過承受幾種不同類型的表觀遺傳修飾，參與并影響許多細胞進程，如轉(zhuǎn)錄激活/失活、染色體包裝、DNA損傷/修復(fù)。這些修飾，包括甲基化、瓜氨化、乙酰基化、磷酸化、小泛素相關(guān)修飾化、泛素化及二磷酸腺苷核糖基化。主要發(fā)生在組蛋白H3的N末端尾區(qū)域上，這導(dǎo)致核小體結(jié)構(gòu)重構(gòu)成更容易接近的開放構(gòu)象的轉(zhuǎn)錄復(fù)合物。在大多數(shù)物種中，組蛋白H3主要在賴氨酸9,14,18,23和56處乙?；? 在賴氨酸4,9,27,36和79處甲基化; 并分別在ser10，ser28，Thr3和Thr11磷酸化。組蛋白修飾的深入研究能更好地了解細胞過程的表觀遺傳調(diào)控。
西美杰為您整理并推薦Agrisera公司經(jīng)過驗證的，高質(zhì)量的組蛋白表觀遺傳修飾抗體，產(chǎn)品如下：
|
產(chǎn)品名稱 |
貨號 |
適用物種 |
產(chǎn)品詳情 |
|
H3K18me1 | Histone H3 (monomethylated Lys18) |
AS16 3181 |
人 |
|
|
H3K27ac | Histone H3 acetylated lysine 27 (ChIP grade) |
AS16 3195 |
擬南芥、人、小鼠、大鼠 |
|
|
H3K27me3 | Histone H3, trimethylated lysine 27 (H3K27me3) |
AS16 3193 |
擬南芥、人、楊樹、玉米等 |
|
|
H3K37me1 | Histone H3 (Monomethylated Lys37) |
AS16 3186 |
人 |
|
|
H3K4me3 | Histone H3, trimethylated lysine 4 |
AS16 3190 |
擬南芥、人等 |
|
|
H3K56me1 | Histone H3 (monomethylated Lys56) |
AS16 3187 |
人 |
|
|
H3K9ac | Histone H3, acetylated lysine 9 |
AS16 3198 |
擬南芥、人等 |
|
|
H3K9me2 | Histone H3 dimethylated lysine 9 |
AS16 3194 |
人、番茄 |
|
|
H3R2me1 | Histone H3 (monomethylated Arg2) |
AS16 3167 |
秀麗隱桿線蟲、人 |
|
|
H3S10p | Histone H3 (p Ser10) (affinity purified) |
AS16 3635 |
人 |
注：產(chǎn)品名稱命名方式以組蛋白名稱開始，如H3；單一字母的氨基酸簡稱，如K代表賴氨酸，以及在蛋白質(zhì)的位置；修飾的種類，Me即甲基化、P即磷酸化、Ac即乙?；?/span>、Ub即泛素化。
為滿足廣大表觀遺傳學(xué)研究方向客戶的需求，西美杰聯(lián)合專業(yè)抗體品牌Agrisera推出表觀遺傳學(xué)相關(guān)抗體促銷活動！
活動內(nèi)容如下：
活動時間：即日起至6月30日
活動對象：僅限終端客戶參加
促銷規(guī)則：促銷產(chǎn)品限時“7折”特惠
促銷產(chǎn)品：除上述小編列舉的組蛋白表觀遺傳修飾抗體外，更有50多種表觀遺傳學(xué)相關(guān)抗體正在進行促銷，請見以下促銷產(chǎn)品清單：
|
產(chǎn)品名稱 |
產(chǎn)品貨號 |
|
5-fC | 5-formylcytosine |
AS16 3165 |
|
5-hmC | 5-hydroxymethylcytosine (monoclonal) |
AS16 3164 |
|
5-hmC | 5-hydroxymethylcytosine (polyclonal) |
AS16 3166 |
|
5-mC | 5-methylcystosine (monclonal antibody for MeDIP/IF) |
AS16 3162 |
|
5-mC | 5-methylcystosine (monclonal) |
AS16 3161 |
|
5-mC | 5-methylcystosine (monclonal, clone 33D3) |
AS16 3163 |
|
Acetylated lysine (25 μl, clone 7F8) |
AS10 707-25 |
|
Acetylated Lysine (polyclonal) |
AS15 3018 |
|
Acetylated Lysine, ALP conjugated |
AS15 3019 |
|
Acetylated Lysine, FITC conjugated |
AS15 3020 |
|
H2A.XS139p | H2A.X phosphorylated serine 139 |
AS16 3199 |
|
H3 | Histone 3 core | (monoclonal) |
AS16 3197 |
|
H3K18me1 | Histone H3 (monomethylated Lys18) |
AS16 3181 |
|
H3K18me2 | Histone H3 (dimethylated Lys18) |
AS16 3182 |
|
H3K18me3 | Histone H3 (trimethylated Lys18) |
AS16 3183 |
|
H3K27ac | Histone H3 acetylated lysine 27 (ChIP grade) |
AS16 3195 |
|
H3K27me3 | Histone H3, trimethylated lysine 27 (H3K27me3) |
AS16 3193 |
|
H3K27me3S28p | Histone H3 (trimethylated Lys27, p Ser28) |
AS16 3184 |
|
H3K36me3 | Histone H3 trimethylated lysine 36 (ChIP grade) |
AS16 3196 |
|
H3K37me1 | Histone H3 (Monomethylated Lys37) |
AS16 3186 |
|
H3K4me1T6p | Histone H3 (monomethylated Lys4, p Thr6) |
AS16 3171 |
|
H3K4me3 | Histone H3, trimethylated lysine 4 (H3K4me3) |
AS16 3190 |
|
H3K4me3 | Histone H3, trimethylated lysine 4 (H3K4me3) (10 μg) |
AS16 3190-10 |
|
H3K4me3T6p | H3 (trimethylated Lys4, p Thr6) |
AS16 3172 |
|
H3K56me1 | Histone H3 (monomethylated Lys56) |
AS16 3187 |
|
H3K56me3 | Histone H3 (trimethylated Lys56) |
AS16 3188 |
|
H3K9ac | Histone H3, acetylated lysine 9 |
AS16 3198 |
|
H3K9me2 | Histone H3 dimethylated lysine 9 |
AS16 3194 |
|
H3R17me2(asym) | Histone H3 (asym-dimethyl Arg17) |
AS16 3180 |
|
H3R2me1 | Histone H3 (monomethylated Arg2) |
AS16 3167 |
|
H3R2me2(sym)K4me2 | Histone H3 (sym-dimethylated Arg2, dimethyl Lys4) |
AS16 3185 |
|
H3R8me2(asym) | Histone H3 (asym-dimethylated Arg8) |
AS16 3177 |
|
H3R8me2(sym) | H3 Histone 3 (sym-dimethylated Arg8) |
AS16 3178 |
|
H3S10p | Histone H3 (p Ser10) (affinity purified) |
AS16 3635 |
|
H3S10p | Histone H3 (p Ser10) (affinity purified, 10 μl) |
AS16 3635-10 |
|
H3S10p | Histone H3 (p Ser10) (serum) |
AS16 3636 |
|
H3S10pT11p | Histone H3 (p Ser10, p Thr11) |
AS16 3179 |
|
H3T3pK4ac | Histone H3 (ac Lys4, p Thr3) |
AS16 3170 |
|
H3T3pK4me1 | Histone H3 (p Thr3, monomethylated Lys4) |
AS16 3168 |
|
H3T3pK4me2 | Histone H3 (dimethylated Lys4, p Thr3) |
AS16 3169 |
|
H3T6p | Histone H3 (p Thr6) |
AS16 3173 |
|
H3T6pK9me1 | Histone H3 methylated at Lys9 (K9) |
AS16 3174 |
|
H3T6pK9me2 | Histone H3 (dimethylated Lys9, p Thr6) |
AS16 3175 |
|
H3T6pK9me3 | Histone H3 (trimethylated Lys9, p Thr6) |
AS16 3176 |
|
H4K16ac | Histone H4 (ac Lys16) |
AS16 3189 |
|
m6A | N6-methyladenosine (monoclonal) |
AS17 4120 |
|
m6A | N6-methyladenosine (polyclonal) |
AS17 4121 |
|
Methylated Lysine |
AS15 3021 |
|
Methylated Lysine, APC conjugated |
AS15 3022 |
|
Methylated Lysine, FITC conjugated |
AS15 3023 |
西美杰做為Agrisera中國區(qū)代理為廣大客戶提供經(jīng)過驗證的高質(zhì)量抗體，優(yōu)質(zhì)的售前咨詢服務(wù)以及良好的抗體售后支持。此外西美杰代理的Lifespan、Mybiosource一抗、檢測試劑盒以及SeraCare（KPL）二抗、底物全方位助力于科學(xué)研究實驗。
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